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EFFECT OF AQUEOUS EXTRACTS OF Phyllanthus sellowianus ON THE VISCOELASTIC PROPERTIES OF HUMAN RED BLOOD CELLS: IN VITRO ANTIDIABETIC ACTIVITY

Authors

H. Mascaro Grosso Fac. Cs. Bioquímicas y Farmacéuticas – Universidad Nacional de Rosario – Suipacha 535 – (2000) Rosario – Argentina
P. Buszniez Fac. Cs. Bioquímicas y Farmacéuticas – Universidad Nacional de Rosario – Suipacha 535 – (2000) Rosario – Argentina
H.V. Castellini Fac. Cs. Exactas, Ingeniería y Agrimensura – Universidad Nacional de Rosario – Pellegrini 250 – (2000) Rosario – Argentina
B.D. Riquelme Fac. Cs. Bioquímicas y Farmacéuticas – Universidad Nacional de Rosario – Suipacha 535 – (2000) Rosario – Argentina Grupo de Física Biomédica – IFIR (CONICET-UNR) – Bv. 27 de febrero 210 bis – (2000) Rosario – Argentina

Abstract

Phyllanthus sellowianus Müll (Klotzch) Arg. is a native plant used for diabetes treatment. It is currently of interest to
evaluate its activity on the mechanical properties of human red blood cells to elucidate its mechanism of action as an
antidiabetic. For this, aqueous extracts were prepared by various extractive techniques. Using the Erythrocyte Rheometer, the in vitro effect on the viscoelastic parameters of glycated human red blood cells, as occurs by hyperglycemia
in diabetes, was evaluated. The results obtained from the treatment with the extracts show that they affect erythrocyte
viscoelasticity and can reverse the glycation effects.